Which of the following is NOT a sign of bed bugs?

Large holes in clothing are not typically associated with bed bugs. Bed bugs are known for leaving specific signs of infestation, which mainly include their exoskeletons, fecal stains, and blood stains.

Exoskeleton shells refer to the discarded skins of bed bugs as they grow and molt. These can often be found in areas where bed bugs are active. Poop stains on bedding, which are tiny dark spots, indicate the presence of bed bugs as they excrete digested blood. Blood stains on sheets are also a common sign, often resulting from bed bugs feeding on a host during the night.

In contrast, large holes in clothing are more indicative of damage caused by other pests, such as moths or beetles, rather than the feeding habits or behaviors of bed bugs. Therefore, identifying signs of bed bugs involves looking for the specific indicators related to their activity, which does not include large holes in clothing.